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Current research studies

For information about any of our research please email

RDaSH hosted research

Surviving crying study

Surviving Crying is a trial of a service to support the mental health and coping of parents with excessively crying infants. Around a fifth of infants cry a lot without an apparent reason during the first four months after they are born. This ‘excessive’ infant crying is often called ‘colic’ and blamed on indigestion. Recent evidence shows that only 5% of infants taken to the doctor because of excessive crying are unwell. However, the crying can distress parents and lead to maternal depression, poor parent-child relationships, problems with child development and infant abuse in extreme cases.

More about the surviving crying study

By developing NHS services which support parents whose babies cry excessively, we hope to improve the parents’ wellbeing and coping, infant outcomes, and how NHS money is spent. includes a website. booklet based on website and programme of session (CBT) by a qualified practitioner to support parental coping. This cluster randomised controlled trial will show whether parent or carers who have access to this package become less depressed and cope better with their baby’s crying compared to parent or carers who receive routine NHS support.

Recruitment end date, 31 August 2024.

UK Minds (NCMH)

Grounded Research is conducting a study involving a Biobank and additional assessments called NCMH (National Centre for Mental Health). It aims to understand why some people experience problems with their mental health, by looking for genes and other factors which make some people more likely than others to become ill.

More about NCMH

We hope that the study will improve understanding of these conditions and help find better treatments in the future.

Akrivia Health are working in partnership with Cardiff University and the National Centre for Mental Health (NCMH) on a programme of work designed to establish a precision neuropsychiatry data and bio resource.

This resource will accelerate research into mental health disorders and cognitive function, and hopefully lead to exciting and innovative precision treatment for dementias, bipolar, depression and psychosis.

For recruitment we are looking for participants who have an serious mental illness diagnosis.

We are trying to understand why some people experience problems with their mental health. The purpose of this study is to collect information and samples for genetic, biological, psychological and clinical research.

This will allow us to look for genes and other factors which make some people more likely than others to become ill. We hope that our study will improve understanding of these conditions and help find better treatments in the future.

Recruitment end date, July 2024.

RDaSH sponsored research


Sustainable return to work: A pilot cluster randomised controlled trial of a multicomponent workplace ‘IGLOo’ intervention compared with usual return-to-work support.

RDaSH is the sponsor for the IGLOo trial, a multi centre randomised control trial.

More about IGLOo

Long-term sick leave is a national concern, with the most common reasons being mental health issues.

Employees on sick leave for reasons such as back pain or stroke, are also likely to experience poor mental health during long-term sick leave.

Our research team propose an intervention which consists of an employer educational information pack outlining the scientific evidence on what works best in supporting employees back-to-work and what helps them to stay in work after long-sick leave.

For employees taking long-term sick leave

An online toolkit will be given that outlines step-by-step actions to take to support their mental wellbeing whilst on sick leave, and actions to take when they are ready to return to work.

Within one month of an employee returning to work, online training will be offered to help them make reasonable changes to their job so that their mental wellbeing is supported.

For line managers

Training will be given in how to support their employee on long-term sick leave and how to help them return-to-work.

Online training will be given to line managers so they can support their employee in making reasonable changes.

Recruitment end date, 31 July 2024.


A pilot randomized controlled trial of psychological treatment selection for depression.

The aim is to explore if it feasible for more patients to recover from depression, if they matched to their optimal psychological treatment using artificial intelligence.

More about TherapyMatch-D

Reviews of clinical trials have concluded that different types of psychological interventions for depression are equally efficacious. Therefore, the largest public provider of psychological services in England, talking therapies, routinely offers cognitive behavioural therapy (CBT) and person centred experiential therapy (also known as counselling for depression; PCE-CfD) as frontline treatments.

Despite efforts to improve recovery rates, 1 out of 2 patients accessing any evidence-based psychotherapy usually do not recover from depression. Recent studies have suggested that identifying subgroups of patients that respond differently to diverse treatment modalities or intensity can improve clinical outcomes. One retrospective study used a large routine care dataset of patients who accessed either CBT or PCE-CfD. Researchers found that in about 30% of patients if matched to their optimal treatment using artificial intelligence, patients were twice as likely to recover from depression.

The aim of this study is to pilot the effectiveness of using a treatment selection model based on that prior study. The researchers will explore if it is feasible and effective for more patients to recover from depression by being provided with a treatment recommendation compared to allocation as usual.

Recruitment end date, 1 September 2025.

RDaSH participating site


Nicotine replacement therapy (NRT) provides nicotine without the toxins contained in cigarette smoke. When used with specialist support, it helps pregnant women stop smoking.

The NRT instruction booklet includes use for pre loading, reduction, and lapse recovery. Studies suggest that allowing people to smoke and use NRT together helps with stopping.

More about the SNAP 3

Currently, NHS stop smoking support advises pregnant women not to smoke when using NRT.

This study will test whether relaxing this message could help pregnant women to quit and improve babies’ health.

Recruitment end date, 1 September 2024.


Understanding the medical effects of dangerous drinking to be able to offer better help and advice.

This research study is creating a database of people who drink too much alcohol, either now or in the past.

More about ALLHEAL and Liver

The purpose of this study is to help us understand the medical effects of dangerous drinking so that we can offer better advice and help to people.

Participants will be asked for some data about their drinking and to consent for their medical record to be accessed and data to be recorded in a research database, for example, medical problems and any medications.

RDaSH is a data collection centre for the research database which is maintained by researchers at Leeds Teaching Hospitals.

Recruitment end date, 1 April 2025.


Genetic links to anxiety and depression (GLAD)

Depression and anxiety disorders are the most common psychiatric disorders worldwide, affecting at least 1 in 3 of the population over their lifespan and are highly correlated, both phenotypically and genetically.

More about GLAD

The project was set up to explore risk factors in individuals who have experienced depression and anxiety, including those with a diagnosis of bipolar disorder, OCD, or related disorders, at any time in their lives.

It aims to better understand depression and anxiety in order to find and develop more effective treatments.

Recruitment end date, 31 January 2028.

NCISH mental health

National confidential inquiry into suicide and homicide by people with mental illness.

This study is to collect detailed clinical information on patients of mental health services who die by suicide, or who commit homicide, to make recommendations for policy and clinical practice.

More about NCISH mental health

Participants are patients who were in contact with mental health services in the time prior to death.

Recruitment end date, 31 March 2024.

The DIAMONDS programme

diabetes and mental illness, improving outcomes and self-management (DIAMONDS)

Self-management (which includes taking medications, monitoring symptoms, preventing complications, and leading a healthier lifestyle) is an important part of staying well with a long-term condition. There are many self-management programmes in the NHS to help people with long-term conditions look after themselves, but they often do not address the challenges of people who also have a severe mental illness. The DIAMONDS research programme aims to overcome this problem by developing and testing a self-management intervention that can specifically help people with diabetes and severe mental illness to be healthier.

More about the DIAMONDS programme

The intervention has been developed in partnership with people with mental illness and diabetes, their family members or friends, and the healthcare staff who support them. It has been designed to address challenges to self-management, which include poor motivation due to mental illness symptoms and medication; limited support from others for self-management; beliefs about their ability to engage in self-management; and limited knowledge and skills for long-term condition management. The DIAMONDS intervention is a 6-month programme that consists of daily self-management tasks and 1-to-1 meetings with a trained facilitator.

Recruitment end date, 30 September 2024.

Page last reviewed: May 17, 2024
Next review due: May 17, 2025


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